Alicja Gawęcka, Ewa Stachowska


The use of caloric restriction modulates the activity of FoxO proteins. FoxO is a key regulator of changes in the metabolism of carbohydrates. Under the influence of limited access to food FoxO proteins are activated. FOXO activation is done by deacetylation. The enzymes responsible for the deacetylation of proteins are called sirtuins. Sirtuins are NAD­‍‑dependent proteins, the activity of which is dependent on the metabolic status of the cell. Deacetylation of FoxO leads to an increase in the potential for increased interaction with DNA. In vivo studies have shown that under the influence of calorie restriction sirtuin levels increase in muscle, brain, kidney, or adipose tissue.


FOXO; sirtuins; caloric restriction; molecular mechanism

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