Association between apical periodontitis and risk of cardiovascular diseases – a review of the literature
Abstract
The aim of the study was to present views on the correlation between apical periodontitis (AP) and the risk of cardiovascular diseases (CVD) based on a review of the available literature. A review of PubMed for papers from the years 2011–2020 was conducted. Searched phrases included: apical periodontitis cardio-vascular diseases, apical periodontitis endothelial dysfunction, apical periodontitis myocardial infarction, endodontic lesion CVD. Based on the literature review, it is suspected that there is a positive correlation between AP and the risk of CVD. Further studies are required to examine the prognostic impact of the treatment of AP on CVD.
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Szcześniak P, Michalak Ł, Durasik A, Orszulak-Michalak D. Angiogenin and novel markers in multivessel coronary heart disease. Biofarmacja 2009;65(2):83-7.
Braz-Silva PH, Bergamini ML, Mardegan AP, De Rosa CS, Hasseus B, Jonasson P. Inflammatory profile of chronic apical periodontitis: a liter-ature review. Acta Odontol Scand 2019;77(3):173-80.
Matsuzaki E, Anan H, Matsumoto N, Hatakeyama J, Minakami M, Izumi T. Immunopathology of Apical Periodontitis and Refractory Cases. J Tissue Sci Eng 2016;7(3):1-5.
van der Waal SV, Lappin DF, Crielaard W. Does apical periodontitis have systemic consequences? The need for well-planned and carefully conducted clinical studies. Br Dent J 2015;218(9):513-6.
Sirin DA, Ozcelik F, Uzun C, Ersahan S, Yesilbas S. Association between C-reactive protein, neutrophil to lymphocyte ratio and the burden of apical periodontitis: a case-control study. Acta Odontol Scand 2019;77(2):142-9.
Aarabi G, Schnabel RB, Heydecke G, Seedorf U. Potential impact of oral inflammations on cardiac functions and Atrial fibrillation. Biomolecules 2018;8(3):66.
Pessi T, Karhunen V, Karjalainen PP, Ylitalo A, Airaksinen JK, Niemi M, et al. Bacterial signatures in thrombus aspirates of patients with myocardial infarction. Circulation 2013;127(11):1219-28.
Louhelainen AM, Aho J, Tuomisto S, Aittoniemi J, Vuento R, Karhunen PJ, et al. Oral bacterial DNA findings in pericardial fluid. J Oral Microbiol 2014;6:25835.
Liljestrand JM, Mäntylä P, Paju S, Buhlin K, Kopra KAE, Persson GR, et al. Association of endodontic lesions with coronary artery disease. J Dent Res 2016;95(12):1358-65.
Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. Wytyczne ESC dotyczące prewencji chorób układu sercowo-naczyniowego w praktyce klinicznej w 2016 roku. Kardiol Pol 2016;74(9):821-936.
Patoulias D, Stavropoulos K, Imprialos K, Athyros V, Grassos H, Doumas M, et al. Inflammatory markers in cardiovascular disease; lessons learned and future perspectives. Curr Vasc Pharmacol 2021;19(3):323-42. doi: 10.2174/1570161118666200318104434.
Garrido M, Cárdenas AM, Astorga J, Quinlan F, Valdés M, Chaparro A, et al. Elevated systemic inflammatory burden and cardiovascular risk in young adults with endodontic apical lesions. J Endod 2019;45(2):111-5.
Kimak A, Kimak E, Solski J, Tymczyna B, Bachanek T. Przewlekłe okołowierzchołkowe zapalenie przyzębia, jako czynnik ryzyka miażdżycy i choroby naczyń. Diagn Lab 2017;53(2):79-84.
Hernández-Ríos P, Pussinen PJ, Vernal R, Hernández M. Oxidative stress in the local and systemic events of apical periodontitis. Front Physiol 2017;8:869.
Baszczuk A, Kopczyński Z, Thielemann A. Dysfunkcja śródbłonka naczyniowego u chorych na pierwotne nadciśnienie tętnicze z hiperhomocysteinemią. Postepy Hig Med Dosw (Online) 2014;68:91-100.
Bergandi L, Giuggia B, Alovisi M, Comba A, Silvagno F, Maule M, et al. Endothelial Dysfunction Marker Variation in Young Adults with Chronic Apical Periodontitis before and after Endodontic Treatment. J Endod 2019;45(5):500-6.
Cotti E, Dessì C, Piras A, Flore G, Deidda M, Madeddu C, et al. Association of endodontic infection with detection of an initial lesion to the cardiovascular system. J Endod 2011;37(12):1624-9.
Jaroszyński A, Jaroszyńska A, Wysokiński A. Asymetryczna dimetyloarginina – ogniwo łączące choroby serca i nerek? Chor Serca Naczyń 2012;9(5):225-9.
Chauhan N, Mittal S, Tewari S, Sen J, Laller K. Association of Apical Periodontitis with Cardiovascular Disease via Noninvasive Assessment of Endothelial Function and Subclinical Atherosclerosis. J Endod 2019;45(6):681-90.
Zhang J, Huang X, Lu B, Zhang C, Cai Z. Can apical periodontitis affect serum levels of CRP, IL-2, and IL-6 as well as induce pathological changes in remote organs? Clin Oral Investig 2016;20(7):1617-24.
Samuel RO, Gomes-Filho JE, Azuma MM, Sumida DH, de Oliveira SHP, Chiba FY, et al. Endodontic infections increase leukocyte and lymphocyte levels in the blood. Clin Oral Investig 2018;22(3):1395-401.
Kabak Y, Abbott PV. Prevalence of apical periodontitis and the quality of endodontic treatment in an adult Belarusian population. Int Endod J 2005;38(4):238-45.
Liccardo D, Cannavo A, Spagnuolo G, Ferrara N, Cittadini A, Rengo C, et al. Periodontal disease: a risk factor for diabetes and cardiovascular disease. Int J Mol Sci 2019;20(6):1414.
Chistiakov DA, Orekhov AN, Bobryshev YV. Links between atherosclerotic and periodontal disease. Exp Mol Pathol 2016;100(1):220-35.
Alim BA, Guneser MB, Dincer AN. Cardiologists’ and cardiovascular surgeons’ attitudes toward managing endodontic infections and oral health in patients with cardiovascular diseases. Postgrad Med 2020;132(2):156-61.
DOI: https://doi.org/10.21164/pomjlifesci.767
Copyright (c) 2021 Marta Raciborska, Małgorzata Pawińska
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